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Inhibition of RB tumor suppressor activity increases chemosensitivity in lung cancer xenografts

✍ Scribed by M.F. Reed; W.A. Zagorski; A. Dhamija; E.S. Knudsen


Book ID
116702382
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
51 KB
Volume
130
Category
Article
ISSN
0022-4804

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## Abstract Epigenetic changes involved in cancer development, unlike genetic changes, are reversible. DNA methyltransferase and histone deacetylase inhibitors show antiproliferative effects __in vitro__, through tumor suppressor reactivation and induction of apoptosis. Such inhibitors have shown a