Inhibition of renal clearance of furosemide by pentopril, an angiotensin—converting enzyme inhibitor
✍ Scribed by Rakhit, Ashok; Kochak, Gregory M; Tipnis, Vijay; Hurley, Margaret E
- Book ID
- 109844284
- Publisher
- Nature Publishing Group
- Year
- 1987
- Tongue
- English
- Weight
- 530 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0009-9236
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The goal of this study was to quantitate the effect of angiotensin-converting enzyme inhibition on renal sodium handling after furosemide injection. The study was carried out on low and normal salt intake to assess potential interaction with salt balance. Eighteen healthy normotensive volunteers wer
The disposition characteristics of pentopril (the ethyl ester) and its active carboxylic acid metabolite (CGS 13934) were determined in conscious rats after separate intravenous administrations of both compounds. The relationship between plasma concentration and pharmacological effect was also evalu