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Inhibition of protein synthesis by trimethyltin

โœ Scribed by Lucio G. Costa; Rini Sulaiman


Book ID
113206649
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
683 KB
Volume
86
Category
Article
ISSN
0041-008X

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The antitumor natural product RA-VII has been evaluated as an inhibitor of protein synthesis in vitro. Complete inhibition of protein synthesis in rabbit reticulocyte lysates is observed with \(5 \mu \mathrm{m}\) RA-VII. Mechanistic studies using purified elongation factors and ribosomes identify RA