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Inhibition of potassium outward currents and pacemaker current in sheep cardiac Purkinje fibres by the verapamil derivative YS 035

โœ Scribed by F. Berger; U. Borchard; D. Hafner; T. Kammer; T. Weis


Book ID
112276402
Publisher
Springer-Verlag
Year
1991
Tongue
English
Weight
1020 KB
Volume
344
Category
Article
ISSN
0028-1298

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Block of the cardiac pacemaker current (
โœ D. DiFrancesco; F. Porciatti; D. Janigro; G. Maccaferri; M. Mangoni; T. Tritella ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› Springer ๐ŸŒ English โš– 508 KB

We have investigated the action of 9-amino-1, 2, 3, 4-tetrahydroacridine (THA) on the pacemaker current If in rabbit sino-atrial node myocytes and in canine Purkinje fibers. THA at concentrations in the range 3-300 microM blocked If in a voltage-independent manner, as revealed by measurements on the