The contribution of Na and K ions to the pacemaker current in sheep cardiac Purkinje fibres
β Scribed by H. G. Glitsch; H. Pusch; F. Verdonck
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 880 KB
- Volume
- 406
- Category
- Article
- ISSN
- 0031-6768
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π SIMILAR VOLUMES
The effects of the cardioplegic solution HTK on membrane potential (EM) and intracellular K and Na activities (a~, a~a) were studied in sheep cardiac Purkinje fibres by means of conventional and ion-selective microelectrodes. HTK contains (raM): Na 15, K 10, Ca 0, Mg 4, histidine 180. (1) In control
We have investigated the action of 9-amino-1, 2, 3, 4-tetrahydroacridine (THA) on the pacemaker current If in rabbit sino-atrial node myocytes and in canine Purkinje fibers. THA at concentrations in the range 3-300 microM blocked If in a voltage-independent manner, as revealed by measurements on the