Inhibition of Parietal Cell Acid Secretion Is Mediated by the Classical Epidermal Growth Factor Receptor
β Scribed by Virendra Joshi; Gregory S. Ray; James R. Goldenring
- Book ID
- 110377255
- Publisher
- Springer US
- Year
- 1997
- Tongue
- English
- Weight
- 157 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0163-2116
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The growth inhibitory effects of exogenously added retinoic acid (RA) on various cultured human glioma cells was observed to be heterogenous, with an ID,, ranging from lo-' M to no response. The protein tyrosine kinase activity of epidermal growth factor receptor (EGF-receptor) appeared to parallel
## Abstract Inhibiting epidermal growth factorβreceptor (ErbBβ1) represents a powerful anticancer strategy. Activation of retinoid pathways is also in development for cancer treatment. Retinoic acid receptorβΞ²βthe tumor suppressor and main retinoid mediatorββis silenced in many tumors. The ErbBβ1 i