𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Inhibition of epidermal growth factor receptor activity by retinoic acid in glioma cells

✍ Scribed by Peter A. Steck; Azra Hadi; Reuben Lotan; W. K. Alfred Yung

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
791 KB
Volume
42
Category
Article
ISSN
0730-2312

No coin nor oath required. For personal study only.

✦ Synopsis

The growth inhibitory effects of exogenously added retinoic acid (RA) on various cultured human glioma cells was observed to be heterogenous, with an ID,, ranging from lo-' M to no response. The protein tyrosine kinase activity of epidermal growth factor receptor (EGF-receptor) appeared to parallel the cell's growth responsiveness to RA. Cells sensitive to RA-induced growth inhibition exhibited a dose-dependent decrease in EGF-receptor activity, whereas RA-resistant cells showed no alterations in EGF-receptor protein tyrosine kinase activity or expression. The modulation of EGF-receptor by RA was further examined with RA-sensitive (LG) and -resistant (NG-I ) cell lines. Both cell lines were approximately equal in their ability to bind and internalize epidermal growth factor in the presence or absence of RA. Several independent assays suggested that the inhibition of EGF-receptor activity was independent of protein kinase C modulation as mediated by phorbol myristate acetate. However, alterations in associated glycoconjugates of EGF-receptor were observed among the sensitive cells but not the resistant cells. These results suggest RA-induced growth inhibition in sensitive cells may arise, at least in part, through alterations in EGF-receptor activity and structure.

πŸ“œ SIMILAR VOLUMES

Protein phosphatase activity of PTEN inh
Protein phosphatase activity of PTEN inhibited the invasion of glioma cells with epidermal growth factor receptor mutation type III expression
✍ Xiu-Mei Cai; Bei-Bei Tao; Li-Ying Wang; Yu-Long Liang; Jia-Wei Jin; Yong Yang; Y πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 French βš– 457 KB

## Abstract __PTEN__ is a major tumor suppressor gene that has been shown to inhibit cell invasion. Its mutation has been found in 20–40% of malignant gliomas. Meanwhile, the type III EGFR mutation (EGFRvIII), which was frequently found in gliomas, promoted cell invasion. In the present study, the

Modulation of transforming growth factor
Modulation of transforming growth factor alpha-dependent expression of epidermal growth factor receptor gene by transforming growth factor beta, triiodothyronine, and retinoic acid
✍ J. A. Fernandez-Pol; D. J. Klos; P. D. Hamilton πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 English βš– 692 KB

We have investigated the actions of transforming growth factor (TGF) type a on epidermal growth factor (EGF) receptor mRNA expression in MDA-468 human mammary carcinoma cells in serum-free media. We found that exposure of MDA-468 cells to TGFa results in elevated levels of EGF receptor mRNA. This in

Dexamethasone and retinoic acid regulate
Dexamethasone and retinoic acid regulate the expression of epidermal growth factor receptor mRNA by distinct mechanisms
✍ Kerby C. Oberg; Graham Carpenter πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 902 KB

## Abstract Retinoic acid and dexamethasone have antagonistic effects on epidermal growth factor (EGF) receptor expression in fetal rat lung (FRL) cells: Receptor synthesis is enhanced by retinoic acid and reduced by dexamethasone. In the presence of actinomycin D, neither agent has the capacity to

Inhibition of epidermal growth factor-in
Inhibition of epidermal growth factor-induced cell transformation and Akt activation by caffeine
✍ Masaaki Nomura; Daisuke Ichimatsu; Shuzo Moritani; Ichiko Koyama; Zigang Dong; K πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 296 KB

## Abstract We found that caffeine significantly inhibited epidermal growth factor (EGF)‐ and 12‐__O__‐tetradecanoylphorbol‐13‐acetate (TPA)‐induced cell transformation in the JB6 mouse epidermal cell line. The tumor promoter‐induced cell transformation was also blocked by treatment with an adenosi

Spontaneous activation and signaling by
Spontaneous activation and signaling by overexpressed epidermal growth factor receptors in glioblastoma cells
✍ Christopher Y. Thomas; Michael Chouinard; Michael Cox; Sarah Parsons; Melody Sta πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 French βš– 482 KB

## Abstract Overexpressed epidermal growth receptor factor receptors (EGFRs) are thought to contribute to the malignant phenotype of human glioblastomas (GBMs), but the mechanism is not well understood. We found that SKMG‐3 cells, a rare GBM cell line that maintains EGFR gene amplification __in vit