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Inhibition of pancreatic colipase by antibodies and Fab fragments. Selective effects of two fractions of antibodies on the functional sites of the cofactor

✍ Scribed by I. Bosc-Bierne; C. Perrot; L. Sarda; J. Rathelot


Book ID
113265851
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
769 KB
Volume
827
Category
Article
ISSN
0167-4838

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The anticancer agent neocarzinostatin (NCS) was bound covalently to human/mouse chimeric Fab fragments of the monoclonal antibody A7 to form the conjugate chA7Fab-NCS. The antitumor effect of chA7Fab-NCS was tested by measuring the inhibition of 3H-thymidine incorporation into human pancreatic carci