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Inhibition of p38 MAP Kinase Activity Up-Regulates Multiple MAP Kinase Pathways and Potentiates 1,25-Dihydroxyvitamin D3-Induced Differentiation of Human Leukemia HL60 Cells

✍ Scribed by Xuening Wang; Jie Rao; George P. Studzinski

Book ID
115603736
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
585 KB
Volume
258
Category
Article
ISSN
0014-4827

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Inhibition of p38MAP kinase potentiates
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## Abstract Monocytic differentiation of HL60 cells induced by 1,25‐dihydroxyvitamin D~3~ (1,25 D~3~) has been recently shown (Exp Cell Res 258, 425, 2000) to be enhanced by an exposure to SB203580 or to SB202190, specific inhibitors of p38MAP kinase, with concomitant up‐regulation of the c‐jun N t

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Activation of ERK1 and ERK2 protein kinases has been implicated in diverse cellular processes, including the control of cell proliferation and cell differentiation (Marshall [1995] Cell 80:179). In human myeloblastoid leukemia HL60 cells rapid (ca. 15 min) but transient activation of ERK1/2 has been