Inhibition of P-glycoprotein Over-expression by shRNA-mdr1b in Rat Astrocytes
β Scribed by Lei Chen; Xinwang Cheng; Linyu Tian; Tianhua Yang; Stefan Hermann; Dong Zhou
- Book ID
- 106484123
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 398 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0364-3190
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Mammalian liver exhibits expression of members of the family of multidrug resistance (mdr) transporters (P-glycoproteins). P-glycoprotein isoforms encoded by mdr1 genes participate in extrusion of an array of xenobiotics into the bile. Induction of mdr1b mRNA expression has been shown to occur in ra
Although it has been well established that the drug efflux pump P-glycoprotein (P-gp) protects the brain against the entry of cytotoxic drugs, its real in situ localization, i.e., at brain capillary endothelial cells or on astrocyte foot processes, is still controversial. The aim of this study was t
Fatty acid ester surfactants Cremophor EL and Solutol H S I 5 were described earlier as modulators of multidrug resistance mediated by MDR I P-glycoprotein (Pgp). We have shown that the most active components of these polydisperse surfactants are fatty acid-polyethylene glycol-fatty acid diesters (F