Contribution of mdr1b-type P-glycoprotein to okadaic acid resistance in rat pituitary GH3cells

Using real-time quantitative TaqMan RT-P

Using real-time quantitative TaqMan RT-PCR to evaluate the role of dexamethasone in gene regulation of rat P-glycoproteins mdr1a/1b and cytochrome P450 3A1/2

✍ Qin Mei; Karen Richards; Kristie Strong-Basalyga; Scott E. Fauty; Anne Taylor; M 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 159 KB 👁 1 views

Cytochromes P450 (CYPs) and p-glycoproteins (Pgps) are believed to play important roles in drug absorption, metabolism, and elimination. Numerous drugs and environmental chemicals can modulate expression of these two classes of genes in different species. The present study investigated the effect of