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Inhibition of P-glycoprotein-mediated transport by extracts of and monoterpenoids contained in Zanthoxyli Fructus

✍ Scribed by Naoko Yoshida; Akiyoshi Takagi; Hidenori Kitazawa; Junichi Kawakami; Isao Adachi


Book ID
113923698
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
397 KB
Volume
209
Category
Article
ISSN
0041-008X

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To study the effect of bile acids on P-glycoproteinmediated drug transport, we performed experiments using multidrug resistant cells and rat canalicular membrane vesicles. Cellular accumulation and efflux of rhodamine 123 were measured in drug-resistant cells by means of computerized quantitative im