Inhibition of normal rat macrophage functions by soluble tumor products

✍ Scribed by Daniela Iannello; Letterio Bonina; Demetrio Delfino; Maria Concetta Berlinghieri; Pasquale Mastroeni

• Publisher: Springer-Verlag
• Year: 1984
• Tongue: English
• Weight: 450 KB
• Volume: 17
• Category: Article
• ISSN: 0340-7004
• DOI: 10.1007/bf00205495

✦ Synopsis

The phagocytic and chemotactic activities of normal rat peritoneal macrophages were inhibited by sera from tumor-bearing rats (TBR) and 3 M KCl extracts of tumor mass. However, sera from Corynebacterium parvum- or Listeria monocytogenes-treated TBR did not inhibit phagocytosis. On the other hand, sera from C. parvum-treated, but not from L. monocytogenes-treated TBR still inhibited the chemotactic response of the normal macrophages. Furthermore, 3 M KCl extracts of tumors from C. parvum-treated TBR did not inhibit phagocytosis and chemotactic response of the same cells. Similar results were obtained with extracts of tumor masses from L. monocytogenes-treated rats. It is suggested that treatment with bacterial immunomodulators can influence the release from neoplastic cells of soluble products influencing normal macrophage functions.