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Inhibition of NO synthase increases the severity of kainic acid-induced seizures in rodents

✍ Scribed by LaRoy P. Penix; Wendy Davis; Swaminathan Subramaniam


Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
906 KB
Volume
18
Category
Article
ISSN
0920-1211

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## Abstract Kainic acid (KA)‐induced status epilepticus (SE) is a well‐characterized model of excitotoxic neuronal injury. Excitotoxicity results from activation of specific glutamate receptors, with resultant elevation of intracellular Ca^2+^. The CA1 and CA3 subregions of the hippocampus are espe