The effects of nitric oxide synthase (NOS) inhibitors, N(omega)-nitro-L-arginine and 7-nitroindazole, and the NOS substrate L-arginine on kainic acid (KA)-induced microglial reactivity and stress response were studied in the hippocampus 7 and 1 days after KA, respectively. Density of peripheral-type
Inhibition of NO synthase increases the severity of kainic acid-induced seizures in rodents
β Scribed by LaRoy P. Penix; Wendy Davis; Swaminathan Subramaniam
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 906 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0920-1211
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Seizure activity induced by kainic acid (KA) and subsequent neuronal death are thought to be associated with an increase in cytoplasmic free calcium ([Ca2+li) and can be prevented by N-methyl-D-aspartate (NMDA) antagonists. In addition to influx through receptor operated Ca2+ channels the increase i
## Abstract Kainic acid (KA)βinduced status epilepticus (SE) is a wellβcharacterized model of excitotoxic neuronal injury. Excitotoxicity results from activation of specific glutamate receptors, with resultant elevation of intracellular Ca^2+^. The CA1 and CA3 subregions of the hippocampus are espe