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Inhibition of nitric oxide production from lipopolysaccharide-treated RAW 264.7 cells by synthetic flavones: Structure-activity relationship and action mechanism

✍ Scribed by Soo Jin Kim; Haeil Park; Hyun Pyo Kim


Publisher
Springer
Year
2004
Tongue
English
Weight
659 KB
Volume
27
Category
Article
ISSN
0253-6269

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A new pyrrolidinone diterpenoid, excisusin F (1), was isolated from the aerial parts of Isodon excisus (Lamiaceae), together with four known compounds, and their structures were determined mainly by NMR (1D and 2D) and mass spectrometry. Excisusin F (1) and inflexarabdonin E (3) showed potent inhibi