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Pyrrolidinone diterpenoid from Isodon excisus and inhibition of nitric oxide production in lipopolysaccharide-induced macrophage RAW264.7 cells

✍ Scribed by Seong Su Hong; Seon A Lee; Nahyun Kim; Ji Sang Hwang; Xiang Hua Han; Mi Kyeong Lee; Jae Kyung Jung; Jin Tae Hong; Youngsoo Kim; Dongho Lee; Bang Yeon Hwang

Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 214 KB
Volume: 21
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.11.095

No coin nor oath required. For personal study only.

✦ Synopsis

A new pyrrolidinone diterpenoid, excisusin F (1), was isolated from the aerial parts of Isodon excisus (Lamiaceae), together with four known compounds, and their structures were determined mainly by NMR (1D and 2D) and mass spectrometry. Excisusin F (1) and inflexarabdonin E (3) showed potent inhibitory effects of LPS-induced nitric oxide production in RAW264.7 cells with the IC 50 value of 10.4 and 3.8 lM, respectively.

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