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Inhibition of neutrophil chemotaxis by protease inhibitors. Differential effect of inhibitors of serine and thiol proteases

✍ Scribed by Jennifer B. Barna; Richard R. Kew


Publisher
Springer
Year
1995
Tongue
English
Weight
756 KB
Volume
19
Category
Article
ISSN
0360-3997

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We have studied an indirect role of serine and thiol proteases in the activation of human neutrophils in vitro. Stimulation was evaluated using a chemiluminescence (CL) generation system. Receptor-dependent and receptor-independent stimuli were studied, e.g. opsonized zymosan, formyl-methionyl-leucy

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## Abstract Effects of protease inhibitors on development of mouse blastocysts and fibrinolytic activity of trophoblast were examined by growing embryos on monolayers of decidual cells in the presence of inhibitors. Nitrophenol‐p‐guanidino benzoate (NPGB) was the most effective inhibitor; 10^βˆ’4^ M