Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane
✍ Scribed by Grzegorzewicz, Anna E; Pham, Ha; Gundi, Vijay A K B; Scherman, Michael S; North, Elton J; Hess, Tamara; Jones, Victoria; Gruppo, Veronica; Born, Sarah E M; Korduláková, Jana; Chavadi, Sivagami Sundaram; Morisseau, Christophe; Lenaerts, Anne J; Lee, Richard E; McNeil, Michael R; Jackson, Mary
- Book ID
- 120012681
- Publisher
- Nature Publishing Group
- Year
- 2012
- Tongue
- English
- Weight
- 762 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1552-4450
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Trans mycolic acid content is directly related to cell wall fluidity and permeability in mycobacteria. Carbon-13 NMR spectroscopy of mycolic acids isolated from Mycobacterium tuberculosis (MTB) and Mycobacterium smegmatis (MSM) fed 13 C-labeled precursor molecules was used to probe the biosynthetic
The plasma __membrane of Mycobacterium tuberculosis__ is likely to contain proteins that could serve as novel drug targets, diagnostic probes or even components of a vaccine against tuberculosis. With this in mind, we have undertaken proteome analysis of the membrane of __M. tuberculosis__ H37Rv. Is