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A Common Mechanism of Inhibition of the Mycobacterium tuberculosis Mycolic Acid Biosynthetic Pathway by Isoxyl and Thiacetazone

✍ Scribed by Grzegorzewicz, A. E.; Kordulakova, J.; Jones, V.; Born, S. E. M.; Belardinelli, J. M.; Vaquie, A.; Gundi, V. A. K. B.; Madacki, J.; Slama, N.; Laval, F.; Vaubourgeix, J.; Crew, R. M.; Gicquel, B.; Daffe, M.; Morbidoni, H. R.; Brennan, P. J.; Quemard, A.; McNeil, M. R.; Jackson, M.


Book ID
118022330
Publisher
The American Society for Biochemistry and Molecular Biology
Year
2012
Tongue
English
Weight
807 KB
Volume
287
Category
Article
ISSN
0021-9258

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Inhibition of Diamino Pelargonic Acid Am
✍ StΓ©phane Mann; Dominique Florentin; Denis Lesage; Thierry Drujon; Olivier Ploux; πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 German βš– 237 KB

## Abstract The mechanism of action of amiclenomycin (**1a**), a naturally occuring inhibitor of diaminopelargonic acid aminotransferase, has been established. The enzyme catalyzes the formation of an aromatic adduct between the inhibitor and pyridoxal‐5′‐phosphate. The structure of the adduct, det