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Inhibition of mRNA synthesis in the hippocampus impairs consolidation and reconsolidation of spatial memory

✍ Scribed by Weber C. Da Silva; Juliana S. Bonini; Lia R.M. Bevilaqua; Jorge H. Medina; Iván Izquierdo; Martín Cammarota

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
447 KB
Volume
18
Category
Article
ISSN
1050-9631

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✦ Synopsis

Abstract

Using two different mRNA synthesis inhibitors, we show that blockade of hippocampal gene expression during restricted posttraining or postretrieval time windows hinders retention of long‐term spatial memory for the Morris water maze task, without affecting short‐term memory, nonspatial learning, or the functionality of the hippocampus. Our results indicate that spatial memory consolidation induces the activation of the hippocampal transcriptional machinery and suggest the existence of a gene expression‐dependent reconsolidation process that operates in the dorsal hippocampus at the moment of retrieval to stabilize the reactivated mnemonic trace. © 2007 Wiley‐Liss, Inc.

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