Inhibition of mouse mammary carcinoma development with doxorubicin in liposomes
โ Scribed by Jan Vaage; Peter Working; Paul Uster
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- French
- Weight
- 35 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
โฆ Synopsis
Monthly treatments with intravenous doxorubicin encapsulated in long circulating, sterically stabilized liposomes delayed the appearance of primary mammary carcinomas and reduced the final incidence from 49 in 50 untreated mice to 46 in 87 treated mice. No toxic side effects of the treatments were observed.
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The purpose of our study was to compare the therapeutic effects of doxorubicin in 3 different formulations: (I) in PBS, (2) in conventional liposomes composed of egg phosphatidylglycerol/ egg phosphatidylcholine/cholesterol/dl-a tocopherol, and (3) in sterically stabilized, long-circulating "Stealth
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