Correlation of toxicity with pharmacokinetics of pegylated liposomal doxorubicin (Doxil) in metastatic breast carcinoma
β Scribed by Olga Lyass; Beatrice Uziely; Rami Ben-Yosef; Dinah Tzemach; Norman I. Heshing; Michal Lotem; George Brufman; Alberto Gabizon
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 137 KB
- Volume
- 89
- Category
- Article
- ISSN
- 0008-543X
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## BACKGROUND. Compared with free drug, sterically stabilized liposomal drug has prolonged circulation time and, thereby, higher tumor selectivity and antitumor activity. The stability in plasma is an important consideration in the formulation of clinically useful liposomal drug. A Phase I study o