Inhibition of mixed leukocyte culture by anti-idiotypic antibodies
β Scribed by H. Binz; Brigitte A. Askonas
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- English
- Weight
- 587 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract A small dose of the IgG~1~ fraction of antiβidiotypic antibody (ΔId 1) raised in guinea pigs against a strain A/J antibody specific for streptococcal Group A carbohydrate sensitizes A/J mice against Group A streptococci. This is opposed to the previously established suppressive function
Previous investigations have suggested that pairs of peptides specified by complementary RNA sequences (termed complementary peptides) can interact with one another. In the light of this finding, we hypothesized that an antibody directed against a peptide might interact with an antibody against its
## Abstract Antiβidiotype antibodies (Ab2) that immunologically mimic tumor antigens are auspicious agents for the active immunization of cancer patients. We have developed W12, a rat monoclonal IgG~1~ Ab2 to MN β14, a murine antiβcarcinoembryonic antigen (CEA) monoclonal antibody. W12 is specific