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Inhibition of Microtubule Assembly by a Complex of Actin and Antitumor Macrolide Aplyronine A

โœ Scribed by Kita, Masaki; Hirayama, Yuichiro; Yoneda, Kozo; Yamagishi, Kota; Chinen, Takumi; Usui, Takeo; Sumiya, Eriko; Uesugi, Motonari; Kigoshi, Hideo


Book ID
124100463
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
440 KB
Volume
135
Category
Article
ISSN
0002-7863

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Cytotoxicity and actin depolymerizing ac
โœ Kiyotake Suenaga; Noriyuki Kamei; Youko Okugawa; Masaki Takagi; Atsushi Akao; Hi ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 322 KB

The artificial analogs of aplyronine A (1), a potent cytotoxic and antitumor macrolide, were synthesized and the structure-activity (cytotoxicity and actin depolymerizing activity) studies were performed; the side chain portion in 1 was found to play a key role in both biological activities.