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Inhibition of mevalonate 5-diphosphate decarboxylase by fluorinated substrate analogs

✍ Scribed by Yongge Qiu; Ding Li


Book ID
116271635
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
325 KB
Volume
1760
Category
Article
ISSN
0304-4165

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Inhibition of mevalonate 5-pyrophosphate
✍ Isidoros Vlattas; James Dellureficio; Edmund Ku; Regine Bohacek; Xiaolu Zhang πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 249 KB

Mevalonate 5-pyrophosphate decarboxylase is involved in the conversion of MevPP to IPP in the biosynthesis of steroids and terpenoids from mevalonate. Based on a hypothetical model of the transition state of this enzymatic transformation we have synthesized novel hydroxyacetyl proline analogs that a