## Background: Matrix metalloproteinase-2 (mmp-2), which degrades the extracellular matrix or the basement membrane, has an essential role in tumor invasion and metastasis. to evaluate the roles of mmp-2, its inhibitor (tissue inhibitor of metalloproteinase-2 [timp-2]), and its activator (membrane-
Inhibition of matrix metalloproteinases by over-expression of tissue inhibitor of metalloproteinase-2 inhibits the growth of experimental hemangiomas
β Scribed by V. Vergani; A. Garofalo; M.R. Bani; P. Borsotti; M. Pelina Parker; T. Drudis; G. Mazzarol; G. Viale; R. Giavazzi; W.G. Stetler-Stevenson; G. Taraboletti
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- French
- Weight
- 180 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0020-7136
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The attachment of the blastocyst to the uterine luminal epithelium and the subsequent invasion by trophoblast cells through the stroma and deciduum occur in a highly regulated manner by remodeling of the extracellular matrix. We investigated the temporal and spatial expression of mRNAs for four matr
Matrix metalloproteinase 2 (MMP-2) plays a crucial role in invasion and metastasis of malignant tumors. Membrane type 1-MMP (MT1-MMP) was originally identified as an activator of MMP-2. Tissue inhibitor of MMP-2 (TIMP-2) was identified as an inhibitor of MMP-2 and MT1-MMP. However, TIMP-2 was report
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