Inhibition of matrix metalloproteinases and inducible nitric oxide synthase by andrographolide in human osteoarthritic chondrocytes
✍ Scribed by Ding, Qian-hai; Ji, Xiao-wei; Cheng, Ye; Yu, Yuan-quan; Qi, Yi-ying; Wang, Xiang-hua
- Book ID
- 120206976
- Publisher
- Springer
- Year
- 2012
- Tongue
- English
- Weight
- 344 KB
- Volume
- 23
- Category
- Article
- ISSN
- 1439-7595
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## Abstract ## Objective To investigate the effects of prostaglandin D~2~ (PGD~2~) on interleukin‐1β (IL‐1β)–induced matrix metalloproteinase 1 (MMP‐1) and MMP‐13 expression in human chondrocytes and the signaling pathways involved in these effects. ## Methods Chondrocytes were stimulated with I
## Objective: To determine the effects of peroxisome proliferator-activated receptor gamma (ppargamma) agonists on interleukin-1 (il-1) induction of nitric oxide (no) and matrix metalloproteinase 13 (mmp-13) in human chondrocytes. ## Methods: Ppargamma expression and synthesis in human chondrocyt