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Nitric oxide synthase isoforms and NF-κB activity in normal and osteoarthritic human chondrocytes: Regulation by inducible nitric oxide

✍ Scribed by S.C. Rosa; F. Judas; M.C. Lopes; A.F. Mendes

Book ID: 116790711
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 580 KB
Volume: 19
Category: Article
ISSN: 1089-8603
DOI: 10.1016/j.niox.2008.07.005

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## Abstract 4‐hydroxynonenal (HNE), a lipid peroxidation end product, is produced abundantly in osteoarthritic (OA) articular tissues and was recently identified as a potent catabolic factor in OA cartilage. In this study, we provide additional evidence that HNE acts as an inflammatory mediator by