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Inhibition of liver microsome-mediated mutagenesis, metabolism and DNA-binding of benzo[a]pyrene and benzo[a]pyrene 7,8-dihydrodiol in the rat following glucose administration

✍ Scribed by Vance, R.E.; Teel, R.W.; Strother, A.


Book ID
122993709
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
690 KB
Volume
50
Category
Article
ISSN
0304-3835

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## Abstract Individual metabolites of benzo (a)pyrene were isolated from rat liver microsomal incubation of the parent hydrocarbon, and subsequently bound to DNA in separate incubations with microsomes. Of the metabolites examined, by far the greatest binding resulted with 7,8‐dihydro‐7,8‐dihydroxy