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Inhibition of leukotriene biosynthesis and lipid peroxidation in biological models by the extract of Cassia fistula

✍ Scribed by Sunil Kumar K. C.; Klaus Müller

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 98 KB
Volume: 12
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199811)12:7<526::aid-ptr346>3.0.co;2-3

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✦ Synopsis

The methanol extract obtained from the fruits of Cassia fistula L. inhibited the 5-lipoxygenase catalysed formation of leukotriene B 4 in bovine polymorphonuclear leukocytes with an IC 50 value of 38 mg/mL. Also, lipid peroxidation in bovine brain phospholipid liposomes induced with 2,2'-azo-bis-(2-amidinopropane) dihydrochloride (AAPH) was inhibited with an IC 50 value of 40 mg/mL. A linear correlation was obtained between the effects of the extract in the two kinds of assays suggesting a redox-based mechanism for the inhibition of the 5-lipoxygenase enzyme.

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