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Inhibition of intestinal P-glycoprotein and effects on etoposide absorption

✍ Scribed by Bee-Lien Leu, Jin-ding Huang

Book ID
120776644
Publisher
Springer
Year
1995
Tongue
English
Weight
522 KB
Volume
35
Category
Article
ISSN
0344-5704

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The purpose of this study is to determine the functional role of P-glycoprotein (P-gp) in intestinal absorption of drugs and to quantitatively predict the in vivo absorption enhancement on P-gp inhibition. In situ single-pass rat ileum permeability and aqueous solubility were measured for a set of 1