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Inhibition of interleukin-2-dependent cytotoxic T-lymphocyte growth by gangliosides

✍ Scribed by William D. Merritt; J.Martyn Bailey; Dov H. Pluznik

Book ID
113132947
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
670 KB
Volume
89
Category
Article
ISSN
0008-8749

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## Abstract Cholera toxin irreversibly activates a 43‐kDa guanosine triphosphate (GTP)‐binding protein by adenosine diphosphate ribosylation, resulting in activation of adenylate cyclase and increased intracellular levels of cyclic adenosine monophosphate (cAMP). Because increases in intracellular