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Inhibition of InhA, the Enoyl Reductase from Mycobacterium tuberculosis , by Triclosan and Isoniazid †

✍ Scribed by Parikh, Sapan L.; Xiao, Guoping; Tonge, Peter J.


Book ID
120589493
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
126 KB
Volume
39
Category
Article
ISSN
0006-2960

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Modification of the NADH of the Isoniazi
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The preferred antitubercular drug isoniazid specifically targets a long-chain enoyl-acyl carrier protein reductase (InhA), an enzyme essential for mycolic acid biosynthesis in__Mycobacterium tuberculosis__. Despite the widespread use of this drug for more than 40 years, its precise mode of action ha