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Inhibition of in vivo proliferation of MDA-PCa-2b human prostate cancer by a targeted cytotoxic analog of luteinizing hormone-releasing hormone AN-207

โœ Scribed by Artur Plonowski; Andrew V Schally; Attila Nagy; Kate Groot; Magdalena Krupa; Nora M Navone; Christopher Logothetis

Book ID
117467135
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
118 KB
Volume
176
Category
Article
ISSN
0304-3835

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## Background: Receptors for luteinizing hormone-releasing hormone (lh-rh) found in prostate cancers might be used for targeting of chemotherapeutic agents. doxorubicin derivative 2-pyrrolinodoxorubicin (an-201) can be linked to carrier analog [d-lys6]lh-rh to form the targeted cytotoxic analog of

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BACKGROUND. Receptors for luteinizing hormone-releasing hormone (LH-RH) are found in about 50% of human breast carcinomas. A highly potent cytotoxic agent, 2-pyrrolinodoxorubicin (AN-201), was linked to the agonist [D-Lys 6 ]LH-RH to form a cytotoxic LH-RH analog, AN-207, that can be targeted to LH-