## Abstract Human hepatocellular carcinoma (HCC) is one of the most common malignancies in Asia and Africa. Human telomerase reverse transcriptase (hTERT) is expressed in HCC but absent in normal human liver cells, which is consistent with the expression pattern of telomerase. In the present study,
Inhibition of human telomerase reverse transcriptase by nonsteroidal antiinflammatory drugs in colon carcinoma
โ Scribed by Hua He; Harry Hua-Xiang Xia; Ji De Wang; Qing Gu; Marie C.M. Lin; Bing Zou; Shiu Kum Lam; Annie O.O. Chan; Man Fung Yuen; Hsiang Fu Kung; Benjamin Chun-Yu Wong
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 193 KB
- Volume
- 106
- Category
- Article
- ISSN
- 0008-543X
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## Abstract ## BACKGROUND The stabilization of telomere lengths by telomerase activation is an important step in carcinogenesis and cell immortalization. Human telomerase reverse transcriptase (hTERT) is the catalytic subunit of this enzyme. The objective of this study was to evaluate the use of r
Telomerase extends telomeric repeats at the ends of linear chromosomes, thereby prolonging the replicative capacity of cells. To investigate possible regulatory mechanisms of telomerase, we measured telomerase enzyme activity, human telomerase RNA (hTR) and human telomerase reverse transcriptase (hT