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Inhibition of human pancreatic elastase II activity on human aortic elastin by human α2-macroglobulin

✍ Scribed by J. Graveline; M. Garret; L. Zourgui; P. Lambin; F. Lefebvre; M. Rabaud


Publisher
Springer
Year
1986
Tongue
English
Weight
599 KB
Volume
42
Category
Article
ISSN
1420-682X

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3R)-and (3S)-N-(2-chloromethylphenyl)-3-bromo-3-fluoroazetidin-2-ones 2 were synthesized via the separation of diastereoisomeric phenylglycinol derivatives of the starting 2,3-dibromo-2-fluoropropanoic acid. Acidic hydrolysis of the hydroxyamides led to the chiral trihalogenopropanoic acids. Then, a