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Inhibition of human liver catechol-O-methyltransferase by tea catechins and their metabolites: Structure–activity relationship and molecular-modeling studies

✍ Scribed by Dapeng Chen; Ching Y. Wang; Joshua D. Lambert; Ni Ai; William J. Welsh; Chung S. Yang

Book ID: 113487516
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 457 KB
Volume: 69
Category: Article
ISSN: 0006-2952
DOI: 10.1016/j.bcp.2005.01.024

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Catechins and procyanidins are major polyphenols in plant-derived foods. Despite intensive studies in recent years, neither their biochemical nor their toxicological properties have been clarified sufficiently. This study aimed to compare the methylation of catechins and procyanidins by the enzyme c