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Inhibition of Human Immunodeficiency Virus 1 Protease in vitro: Rational Design of Substrate Analogue Inhibitors

โœ Scribed by Geoffrey B. Dreyer, Brian W. Metcalf, Thaddeus A. Tomaszek, Thomas J. Carr, Arthur C. Chandler, Lawrence Hyland, Stephen A. Fakhoury, Victoria W. Magaard, Michael L. Moore, James E. Strickler, Christine Debouck and Thomas D. Meek


Book ID
123637385
Publisher
National Academy of Sciences
Year
1989
Tongue
English
Weight
895 KB
Volume
86
Category
Article
ISSN
0027-8424

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## Peptidomimetic Human The human immunodeficiency virus (HIV) codas f o r an u.spartic protease known to be essential $)r retroviral mat urution and replicution. The H I V proteuw can rmignize Phe-Pro and Tyr-Pro sequences as the virus-specific cleuvuge site. These.fi.atures provided a basisJor th