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In vitro metabolism of trazodone by CYP3A: inhibition by ketoconazole and human immunodeficiency viral protease inhibitors

โœ Scribed by Alysa Zalma; Lisa L. von Moltke; Brian W. Granda; Jerold S. Harmatz; Richard I. Shader; David J. Greenblatt


Book ID
118513324
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
149 KB
Volume
47
Category
Article
ISSN
0006-3223

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In Vitro/in Vivo scaling of alprazolam m
โœ Noriko Hirota; Kiyomi Ito; Takafumi Iwatsubo; Carol E. Green; Charles A. Tyson; ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 243 KB ๐Ÿ‘ 1 views

We attempted to predict the in vivo metabolic clearance of alprazolam from in vitro metabolic studies using human liver microsomes and human CYP recombinants. Good correlations were observed between the intrinsic clearance (CL int ) for 4-hydroxylation and CYP3A4 content and between the CL int for a