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Inhibition of human dermal fibroblast proliferation by removal of dermatan sulfate

✍ Scribed by Elizabeth M. Denholm; Elizabeth Cauchon; Catherine Poulin; Paul J. Silver

Book ID
114013146
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
392 KB
Volume
400
Category
Article
ISSN
0014-2999

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We examined the effect of D-penicillamine (DP) and copper sulfate (CuSO,) on human fibroblast proliferation in vitro. DP plus CuSO, inhibited both basal and interleukin-1 (IL-1)-induced tritiated thymidine incorporation into fibroblasts in a dose-and time-dependent manner. Significant inhibition was