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Inhibition of human androgen-independent PC-3 and DU-145 prostate cancers by antagonists of bombesin and growth hormone releasing hormone is linked to PKC, MAPK and c-jun intracellular signalling

✍ Scribed by Anton Stangelberger; Andrew V. Schally; Jozsef L. Varga; Marta Zarandi; Ren-Zhi Cai; Benjamin Baker; Brian D. Hammann; Patricia Armatis; Celia A. Kanashiro

Book ID: 116428728
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 279 KB
Volume: 41
Category: Article
ISSN: 0959-8049
DOI: 10.1016/j.ejca.2005.08.022

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## Background: Hormones like bombesin (bn)/gastrin-releasing peptide (grp) and luteinizing hormone-releasing hormone (lh-rh) and growth factors such as epidermal growth factor (egf) might be involved in the relapse of prostate cancer under androgen ablation therapy. interference with receptors for