Inhibition of HIV entry by extracellular glucuronoxylomannan of Cryptococcus neoformans
β Scribed by Hyun Ah Yi; John C. Panepinto; Amy Jacobs
- Book ID
- 116748770
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 381 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0882-4010
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Cryptococcus neoformans, an opportunistic pathogen, is the fourth leading cause of death among AIDS patients. The yeast's capsule is a major virulence factor, and serotype is related to the chemical structure of glucuronoxylomannan (GXM), its capsular polysaccharide. The GXM from Cap70, a hypocapsul
## Abstract The primary structure of the deβ__O__βacetylated glucuronoxylomannan isolated from __Cryptococcus neoformans__ serotype D was characterized __de novo__ by NMR spectroscopy. Assignment of the ^1^H and ^13^C spectra of the polysaccharide involved a combination of 2D NMR experiments includ