HIV-1 and HIV-2 are co-endemic in certain geographic areas. HIV-2 is more weakly pathogenic than HIV-1, and progression to AIDS occurs less frequently and over a longer period of time. Recent epidemiologic studies suggest that individuals infected with HIV-2 have a lower risk of HIV-1 infection. Bot
β¦ LIBER β¦
Inhibition of HIV-1 proteinase by metal ions
β Scribed by T.C. Woon; R.I. Brinkworth; D.P. Fairlie
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 503 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0020-711X
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## Abstract ## Background HIVβ1 integrase (IN) is an interesting target for the gene therapy of AIDS. Although the __in vivo__ functions are not well characterized, it is thought that IN has pleiotropic effects and plays a central role in the interplay between the virus and the host cell. Expressi