Inhibition of HIV-1 Integrase gene expression by 10-23 DNAzyme
β Scribed by Singh, Nirpendra; Ranjan, Atul; Sur, Souvik; Chandra, Ramesh; Tandon, Vibha
- Book ID
- 113094069
- Publisher
- Indian Academy of Sciences
- Year
- 2012
- Tongue
- English
- Weight
- 339 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0250-5991
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## Abstract ## Background HIVβ1 integrase (IN) is an interesting target for the gene therapy of AIDS. Although the __in vivo__ functions are not well characterized, it is thought that IN has pleiotropic effects and plays a central role in the interplay between the virus and the host cell. Expressi
HIV-1 and HIV-2 are co-endemic in certain geographic areas. HIV-2 is more weakly pathogenic than HIV-1, and progression to AIDS occurs less frequently and over a longer period of time. Recent epidemiologic studies suggest that individuals infected with HIV-2 have a lower risk of HIV-1 infection. Bot