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Inhibition of hepatitis B virus (HBV) by LNA-mediated nuclear interference with HBV DNA transcription

✍ Scribed by Zhen Sun; Wenqing Xiang; Yajuan Guo; Zhi Chen; Wei Liu; Daru Lu


Book ID
116301783
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
603 KB
Volume
409
Category
Article
ISSN
0006-291X

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The deoxyguanosine analog penciclovir (PCV; 9-[4-hydroxy-3-hydroxymethyl-but-1-yl]guanine), has shown potent antiviral activity against herpes viruses and hepadnaviruses. Efficacy against chronic hepatitis B virus (HBV) infection has been demonstrated in an animal model and in recent clinical trials