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Inhibition of hepatic oxidative xenobiotic metabolism by piperonyl butoxide

✍ Scribed by Michael R. Franklin

Book ID
115771157
Publisher
Elsevier Science
Year
1972
Tongue
English
Weight
878 KB
Volume
21
Category
Article
ISSN
0006-2952

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The inhibitory effect of piperonyl butoxide (PBO) on cytochrome P450 was studied by theoretical methods. Binding conformations of PBO were obtained by the recently developed lowmode conformational search within the active site of cytochrome P450 cam . Increased activity of PBO relative to other meth