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Inhibition of H-Ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor gene

✍ Scribed by Tolkacheva, Tatyana; Chan, Andrew M-L

Book ID
110062684
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
491 KB
Volume
19
Category
Article
ISSN
0950-9232

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The PTEN (MMAC1/TEP1) tumor suppressor gene was recently isolated and mapped to human chromosome band 10q23. Homozygous deletions and mutations of PTEN were observed in cell lines and sporadic cancers of the breast, kidney, and central nervous system. Germline mutations in PTEN were recently found i