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Cellular transformation by a FERM domain mutant of the Nf2 tumor suppressor gene

✍ Scribed by Johnson, Kristen C; Kissil, Joseph L; Fry, Jessica L; Jacks, Tyler


Book ID
110066860
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
203 KB
Volume
21
Category
Article
ISSN
0950-9232

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## Abstract Although hydroquinone (HQ) is a rodent carcinogen, because of its lack of mutagenicity in standard bacterial mutagenicity assays it is generally considered a nongenotoxic carcinogen. 2,3,5‐__Tris__‐(glutathion‐__S__‐yl)HQ (TGHQ) is a potent nephrotoxic metabolite of HQ that may play an