Inhibition of growth in oral squamous carcinoma cells by cyclopentenone prostaglandins: comparison with chemotherapeutic agents
β Scribed by T.M.A. Elattar; A.S. Virji
- Book ID
- 117642565
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 498 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0952-3278
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π SIMILAR VOLUMES
We have previously shown that pall trans retinoic acid (RA) inhibits macrocellular growth of a multicellular tumor spheroid model for squamous carcinoma, as measured by spheroid size, but allows for continuing DNA synthesis and cell cycle progression, the two being reconciled by a cell death effect.
## Abstract Cyclin D1 is a wellβknown cell cycle regulator. Recently, its proβsurvival function has been revealed in several tumors. Because increasing expression of cyclin D1 is a common event in oral squamous cell carcinoma (OSCC) and has been correlated with cisplatin resistance, we investigated