𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Modulation of growth and proliferation in squamous cell carcinoma by retinoic acid: A rationale for combination therapy with chemotherapeutic agents

✍ Scribed by Peter G. Sacks; Daniel Harris; Ting-Chao Chou

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
678 KB
Volume
61
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

We have previously shown that pall trans retinoic acid (RA) inhibits macrocellular growth of a multicellular tumor spheroid model for squamous carcinoma, as measured by spheroid size, but allows for continuing DNA synthesis and cell cycle progression, the two being reconciled by a cell death effect. DNA

📜 SIMILAR VOLUMES

Effects of β-all-trans retinoic acid on
Effects of β-all-trans retinoic acid on growth, proliferation, and cell death in a multicellular tumor spheroid model for squamous carcinomas
✍ Peter G. Sacks; Victor Oke; Tracey Vasey; Dennise P. Calkins; Nicholas H. A. Ter 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 820 KB

## Abstract The growth of multicellular tumor spheroids, MTSs, from squamous carcinoma line MDA 886Ln was inhibited by β‐all‐trans retinoic acid (RA). Inhibition occurred within 3 to 5 days of treatment, and MTS size then remained static for up to 2 weeks. Although their growth stopped, 10‐day‐trea

Induction of cell cycle arrest and apopt
Induction of cell cycle arrest and apoptosis by a combined treatment with 13-cis-retinoic acid, interferon-α2a, and α-tocopherol in squamous cell carcinoma of the head and neck
✍ Xin Zhang; Zhuo (Georgia) Chen; Fadlo R. Khuri; Dong M. Shin 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 497 KB

## Abstract ## Background. We have previously conducted phase II trials with a combination of 13‐__cis__‐retinoic acid (13‐cRA), interferon‐α2a (IFN‐α2a), and α‐tocopherol (α‐TF) in patients with advanced oral premalignant lesions and locally advanced head and neck cancer in the adjuvant settings